Improving dose conformality for proton LATTICE via proton ARC therapy
Date:
LATTICE therapy is a three-dimensional spatially fractionated radiotherapy (SFRT) technique that delivers a spatially modulated dose distribution characterized by high-dose peaks and low-dose valleys within the target volume. When integrated with intensity-modulated proton therapy (IMPT), LATTICE therapy benefits from the superior dose conformality of proton Bragg peaks, enabling more precise dose sculpting. However, the clinical implementation of LATTICE therapy using IMPT has been limited by challenges such as suboptimal target coverage and increased dose deposition in adjacent organs-at-risk (OARs). This study introduces a novel proton arc therapy approach to enhance dose coverage while improving OAR sparing, thereby optimizing the delivery of Proton LATTICE therapy.
